Located at the heart of the historic 14th/U Street corridor, Hamiltonian Gallery enjoys a rich cultural cross-fertilization with many historic landmarks, galleries, theaters, and other art and performance spaces. It is situated one block from the U Street-Cardoza stop on the Metro's Yellow/Green Line ( view area map ).

Rapid economic growth and increased urban sophistication have contributed to greater appreciation of new, edgy and creative art practices. In particular, the 14th Street/U Street area has witnessed the rebirth of numerous historical performance spaces (the Studio Theater, the Lincoln Theater, and the Source Theater) as well as an expanding network of new commercial galleries. The area's long historical heritage and vibrant, diverse culture has realized the arts as a catalyst for community growth.

The presence of Hamiltonian Gallery will support the neighborhood's cultural growth, filling a significant gap in the availability of prominent exhibition space for new artists in Washington DC.